Stopping Cancer Tumors From Growing

Austin ( Hybrid Media ) — Moonshot Cancer & Diabetes Concert Tour by BMJSports On Tour Looking For Young Scientist, Biologist And Engineers. To Perform Research On Stopping Cancer Tumors From Growing. The focus area is SWI/SNF, (SWItch/Sucrose Non-Fermentable), is a group of proteins that associate to remodel the way DNA is packaged. Texas A&M University and Texas A&M AgriLife Extension Service — Life Research scientists

now have a deeper understanding of a large switch/sucrose non-fermentable (SWI/SNF) protein complex that plays a pivotal role in plant and human gene expression that causes life-threatening diseases such as cancer. This findings could lead to more targeted therapies and help

with physiological improvements in both crops and animal agriculture. The work may provide an new idea to manipulate the functions of this protein for a better therapeutic strategy for curing human cancers. MicroRNAs are produced in a factory inside cells from long substrates that can be hundreds or thousands of bases and also contain a distinct hairpin-structure.

The factory contains a scissor-like enzyme called Dicer, and some assistants that help to fetch the long substrates. One of the assistants is known as Serrate protein, Zhang said. “Also, the shape of the substrates is very critical for microRNA production,” Zhang said. “If the shapes are changed, then the substrates do not fit the

Dicer scissor and can not be cut, and microRNAs are not made.” “We are interested in finding whether there are other workers in the factory,” Wang said. “We used Serrate protein as a fishing bait to catch the prey; and we caught chromatin-remodeling factor 2 (CHR2).” CHR2 is a SWI2/SNF2 motor protein with ATPase activity, Wang said. “It also has a nickname Braham, after a creator God in Hinduism that has four heads and multiple arms, representing brilliancy and power,” he said. Wang said CHR2 is essential for producing RNA from DNA templates because its ATPase activity breaks down ATP to generate energy. “It loosens chromatin where DNA is packed

so that RNA-producing enzymes can now access the DNA templates to make RNAs including the long substrates for microRNAs,” Wang said.

“This is really surprising. We asked, why does CHR2 leave its own home in the chromatin and elope with Serrate into the microRNA producing factory?” Using the plants that lack CHR2 gene, they found that the long substrates of microRNAs are reduced.